虚拟专辑简介
"Immunomodulation: Mechanisms and Therapeutic Implications" offers a panoramic view of immunology, with discoveries including the T-B cell lineages' foundational role in immunity, the cross-reactivity of T cells in COVID-19-induced hepatitis, the strategic formation of iBALT in pulmonary defenses, the challenges and innovations in mucosal vaccine development, the intricate interactome of CD40 in B cells, the protective significance of TLR5 in neonatal meningitis, and the implications of STAT1 dysregulation in autoimmunity and fungal infections. From cellular origins to vaccine innovation, this collection brings together cutting-edge research in the field of immunology to drive breakthroughs in immunotherapy and disease prevention.
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1. The discovery of T–B cell lineages: An interview with Professor Max D Cooper
hLife Dialogue | T细胞和B细胞谱系的发现，董晨院士对话免疫学泰斗Max D. Cooper教授
通讯作者：董晨, Max D Cooper
2019年9月, 生物医学领域的重要奖项拉斯克基础医学奖（Albert Lasker Basic Medical Research Award）授予来自美国埃默里大学医学院的Max D. Cooper教授，以表彰他为发现B淋巴细胞所做出的重要贡献。该奖项被誉为诺贝尔生理学与医学奖的“风向标”。
引用：
Dong C, Cooper MD. The discovery of T–B cell lineages: An interview with Professor Max D Cooper. hLife 2023; 1: 3–7.
2. Quantitative interactomic of CD40 in primary B cells
hLife Letter | CD40信号揭秘：探索未知蛋白质在复合体中的作用
通讯作者：Romain Roncagalli, Bernard Malissen
本研究成功构建了hCD40OST小鼠模型，阐明了B细胞中CD40信号复合体的组成和作用机制。
引用：
Argenty J, Maturin E, Camus M, et al. Quantitative interactomic of CD40 in primary B cells. hLife 2024; 2: 88–93.
3. T cell cross-reactivity in autoimmune-like hepatitis triggered by COVID-19
hLife Letter | 不明原因儿童严重急性肝炎的新假说——新冠超抗原介导的T细胞交叉反应
通讯作者：李贵登，王健伟
引用：
Liu Y, Wang Y, Peng Z, et al. T cell cross-reactivity in autoimmune-like hepatitis triggered by COVID-19. hLife 2023; 1: 57–61.
4. TLR5 expression marks brain boarder associated macrophages and protects neonatal mice from bacterial meningitis
hLife Letter | 脑膜巨噬细胞TLR5表达帮助新生儿抵抗细菌性脑膜炎感染
通讯作者：张炜、侯亚义、李颜
文章报道了细菌鞭毛蛋白特异性受体TLR5在围产期及新生小鼠的脑膜巨噬细胞上特异性高表达, 并且揭示了TLR5激活对于新生小鼠抵抗细菌性脑膜炎感染的作用, 为神经系统巨噬细胞功能性分区的进一步研究提供了借鉴。
引用：
Ren D, Zhang Z, Zheng X, et al. TLR5 expression marks brain boarder associated macrophages and protects neonatal mice from bacterial meningitis. hLife 2024; 2: 371–376.
5. Dysregulated STAT1 gain-of-function: Pathogen-free autoimmunity and fungal infection
hLife Review | STAT1-GOF突变患者——受自身免疫和真菌感染双重折磨
通讯作者：袁静、卢洪洲
文章综述了STAT1基因功能增强型突变（STAT1-GOF）患者和小鼠模型中存在的潜在遗传、细胞和分子机制以及与真菌感染和无病原体自身免疫相关的诊断和治疗挑战。
引用：
Guo L, Lian D, Gu Y, et al. Dysregulated STAT1 gain-of-function: Pathogen-free autoimmunity and fungal infection. hLife 2024; 2: 397–418.
6. Mucosal immune responses in the lung during respiratory infection: The organization and regulation of iBALT structure
通讯作者：刘翠华、王硕
Highlights
· Inducible bronchus-associated lymphoid tissue (iBALT) plays a crucial role in controlling lung infections.
· iBALT organization is supported by stromal cell activation and immune cell recruitment in response to antigen stimulation.
· The iBALT structure carries out regulatory functions during respiratory virus or Mycobacterium tuberculosis (Mtb) infections.
· iBALT is a critical lymphoid organ in the lung, capable of storing memory lymphocytes, and can be induced by vaccination.
引用：
Gao X, Liu C, Wang S. Mucosal immune responses in the lung during respiratory infection: The organization and regulation of iBALT structure. hLife 2023; 1: 71–82.
7. Mucosal vaccine development for respiratory viral infections
通讯作者：林逸凡，傅阳心，彭华
Highlights
· Very few mucosal vaccines for respiratory viral infectious have been approved, and their efficacy is limited.
· The development of mucosal vaccines needs thorough investigation of the respiratory tract mucosa microenvironment.
· Mucosal adjuvants and delivery systems are critical strategies to enhance the immunogenicity of mucosal vaccines.
· Establishing a clinical standardized evaluation system for mucosal vaccines is urgently needed.
引用：
Lin Y, Hu Z, Fu YX, et al. Mucosal vaccine development for respiratory viral infections. hLife 2024; 2: 50–63.
期刊简介
hLife由高福院士、董晨院士和Jules A. Hoffmann教授（2011诺奖获得者）领衔，是中国科学院微生物研究所主办，中国生物工程学会，浙江大学陈廷骅大健康学院，西湖大学医学院，上海市免疫治疗创新研究院和广州霍夫曼免疫研究所联合支持，与国际出版商爱思唯尔合作的健康科学领域综合性英文期刊。
hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。
hLife是一本金色开放获取期刊，月刊出版；2022年成功入选“中国科技期刊卓越行动计划高起点新刊”；2023年11月正式创刊; 2024年5月被DOAJ收录；2024年8月被Scopus收录。
2026年前hLife接收的稿件免收文章处理费（APC）。
期刊网址：
https://www.sciencedirect.com/journal/hlife