作者|张家慧，唐敏珠
单位|上海交通大学医学院附属瑞金医院无锡分院检验科
各位读者，实验室诊断在AAV的诊疗过程中扮演着“福尔摩斯”的角色，让AAV这个隐匿在暗处的蒙面人无处遁足。实验室人员通过检测能够获得“缉凶线索”，化身“无影之灯”，另医生们更快看清其真实面目，帮助患者尽早揭开其“神秘面纱”。早诊断、早干预能够提高AAV患者生存率，所以再次呼吁大家从现在认识疾病本质，理解早做准备的重要性！
点评专家：孙顺昌，上海交通大学医学院附属瑞金医院检验科主任技师
诊断ANCA相关性血管炎需要综合多方面信息，包括临床表现、实验室检查和组织病理学等。其中ANCA的实验室检测是比较关键的一步，要求实验室检验人员具备丰富的理论基础和技术经验，为临床医生提供更准确的结果，为患者的治疗方案提供一定的指导。作为检验人员，我们应深入学习临床知识，掌握检验结果判读要点，不断提高个人综合能力，更好的为患者和医生服务。
参考文献
（上下滑动查看更多）
[1]Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, et al.Nomenclature of systemic vasculitides. Proposal of an internationalconsensus conference. Arthritis Rheum. 1994 Feb;37(2):187-92.
[2]Kaczmarczyk MS, Jurkiewicz D, Niemczyk S, Rymarz A. Auralmanifestations of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis-diagnosis, symptoms, Treatment. J ClinMed. 2024 Jul 23;13(15):4298.
[3]Cao B, Robinson JE, Winget M, Hunt MH, Carlson R, et al. Thorpe CT.Infection prophylaxis among patients with antineutrophil cytoplasmicantibody (ANCA) vasculitis: a scoping review. Clin Rheumatol. 2024Jul 25.
[4]Geetha D, Jefferson JA. ANCA-associated vasculitis: core curriculum2020. Am J Kidney Dis. 2020 Jan;75(1):124-137.
[5]Takeda S, Watanabe-Kusunoki K, Nakazawa D, Kusunoki Y, Nishio S, etal. The pathogenicity of BPI-ANCA in a patient with systemicvasculitis. Front Immunol. 2019 Jun 12; 10:1334.
[6]Konda R, Rajasekaran A, Rizk DV. Antineutrophil cytoplasmicantibody-associated vasculitis. Curr Opin Nephrol Hypertens. 2024 Sep1;33(5):503-511.
[7]田新平,赵丽柯,姜振宇等.抗中性粒细胞胞质抗体相关血管炎诊疗规范[J].中华内科杂志,2022,61(10) : 1128-1135.
[8]Kidney disease: Improving Global Outcomes (KDIGO) ANCA vasculitiswork group. KDIGO 2024 clinical practice guideline for the managementof antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.Kidney Int. 2024 Mar;105(3S): S71-S116.
[9]Paroli M, Gioia C, Accapezzato D. New Insights into Pathogenesis andTreatment of ANCA-Associated Vasculitis: Autoantibodies and Beyond.Antibodies (Basel). 2023 Mar 21;12(1):25.
[10]Chung SA, Langford CA, Maz M, Abril A, Gorelik M, et al. 2021American College of Rheumatology/Vasculitis Foundation Guideline forthe Management of Antineutrophil Cytoplasmic Antibody-AssociatedVasculitis. Arthritis Rheumatol. 2021 Aug;73(8):1366-1383.