免疫锋云会 | 聚焦 ESMO 会议新进展,详解晚期胃癌治疗破局之道

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本文仅供中国大陆地区执业的医学药学专业人士参考,如您非前述专业人士,请离开本页面


免疫和靶向治疗进展层出不穷,不断为晚期胃癌患者的治疗带来新突破。在近日召开的 2024 年欧洲肿瘤内科学会(ESMO)年会上,胃癌领域多项重要研究成果公布,为胃癌治疗的临床实践优化带来更多启示和新希望。


为传递胃癌诊疗前沿,助力消化道肿瘤领域医师诊疗水平的提高,2024 年 10 月 17 日,「免疫锋云会」特邀北京大学国际医院梁军教授担任会议主席,中山大学肿瘤防治中心妙珍教授、河南省肿瘤医院刘莺教授、中国科学技术大学附属第一医院王刚教授线上共聚,解析 2024 ESMO 大会精粹,共同探讨胃癌治疗的破局之道。


材料审批编码:PP-SI-CN-1665

材料审批时间:2024 年 10 月 22 日


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1、正确答案:B

2、正确答案:B


信迪利单抗联合用药安全性信息:在1893 例接受信迪利单抗联合治疗的患者中,3 级及以上不良反应发生率为57.1%,发生率≥1%的不良反应主要为血液学毒性和消化系统毒性[3]

1:Jianming Xu, Haiping Jiang, Yueyin Pan, et al. 2023 AACR. Abs#CT078.

2:国家基本医疗保险、工伤保险和生育保险药品目录(2023年) 

3: 信迪利单抗产品说明书


材料审批编码:PP-SI-CN-1654

材料审批时间:2024年10月15日


✩ 本文仅供医疗卫生等专业人士参考


内容策划:牛艳红

项目审核:王安欣

题图来源:图虫创意



参考文献

[1] 中国临床肿瘤学会(CSCO)胃癌诊疗指南(2024).

[2] Xu J, et al, First-line treatment with sintilimab (sin) vs placebo in combination with chemotherapy (chemo) in patients (pts) with unresectable gastric or gastroesophageal junction (G/GEJ) cancer: Final overall survival (OS) results from the randomized, phase III ORIENT-16 trial. 2023 AACR CT078.

[3] Herrero FR, et al. First-line rilvegostomig (rilve) + chemotherapy (CTx) in patients (pts) with HER2-negative (HER2e) locally advanced unresectable or metastatic gastric cancers: First report of GEMINI-Gastric sub study 2. 2024 ESMO 1422P.

[4] Cruz-Correa M, et al. Tislelizumab (TIS) + chemotherapy (CT) vs placebo (PBO) + CT in HER2-negative advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GC/GEJC): RATIONALE-305 study minimum 3-year survival follow-up. 2024 ESMO 1437P.

[5] Lorenzen S, et al. Modified FOLFOX plus/minus nivolumab and ipilimumab vs FLOT plus nivolumab in patients with previously untreated advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction: Final results of the IKF-AIO-Moonlight trial. 2024 ESMO LBA59.

[6] Peng Z, et al. Phase III study of SHR-1701 versus placebo in combination with chemo as first-line (1L) therapy for HER2-negative gastric/gastroesophageal junction adenocarcinoma (G/GEJA). 2024 ESMO LBA60.

[7] Lonardi S, et al. Final overall survival for the phase III, KEYNOTE-811 study of pembrolizumab plus trastuzumab and chemotherapy for HER2+ advanced, unresectable or metastatic G/GEJ adenocarcinoma. 2024 ESMO 1400O.

[9] Kang YK, et al. First-line (1L) zolbetuximab + chemotherapy in patients (pts) with claudin 18.2 (CLDN18.2) +, HER2-, locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: A pooled final analysis of SPOTLIGHT + GLOW. 2024 ESMO 1438P.

[10] Janjigian YY, et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial. Lancet. 2021;398(10294):27-40.

[11] Shitara K, et al. Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2020;6(10):1571-1580.

[12] Qiu MZ, et al. Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial. BMJ. 2024:385:e078876.

[13] Rha SY, et al. Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2023;24(11):1181-1195.

[14] 中国抗癌协会胃癌专业委员会, 等. 基于PD-L1蛋白表达水平的胃癌免疫治疗专家共识(2023年版). 中国肿瘤临床. 2024;51(2):55-63.

[15] Bang YJ, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687-97.

[16] Finn RS, et al. Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma. N Engl J Med. 2020;382(20):1894-1905.

[17]信迪利单抗产品说明书